| Meksyk - Liga U23 | 04/28 17:30 | 17 | [13] Santos Laguna U23 v Atletico San Luis U23 [3] | L | 0-3 | |
| Meksyk - Liga U23 | 04/21 17:00 | 16 | [16] Santos Laguna U23 v Pachuca U23 [3] | W | 2-1 | |
| Meksyk - Liga U23 | 04/12 15:00 | 15 | [1] Necaxa U23 v Santos Laguna U23 [13] | L | 2-1 | |
| Meksyk - Liga U23 | 04/06 17:00 | 14 | Santos Laguna U23 v Club America U23 | L | 0-2 | |
| Meksyk - Liga U23 | 03/31 15:00 | 13 | [7] Juarez FC U23 v Santos Laguna U23 [12] | L | 2-0 | |
| Meksyk - Liga U23 | 03/15 23:45 | 12 | [18] Tijuana U23 v Santos Laguna U23 [13] | W | 1-5 | |
| Meksyk - Liga U23 | 03/09 17:00 | 11 | [11] Santos Laguna U23 v Cruz Azul U23 [4] | D | 1-1 | |
| Meksyk - Liga U23 | 03/01 15:00 | 10 | [17] Queretaro U23 v Santos Laguna U23 [9] | L | 5-1 | |
| Meksyk - Liga U23 | 02/25 17:00 | 8 | [12] Santos Laguna U23 v Mazatlan FC U23 [15] | W | 3-0 | |
| Meksyk - Liga U23 | 02/21 15:00 | 9 | [7] Toluca U23 v Santos Laguna U23 [14] | D | 0-0 | |
| Meksyk - Liga U23 | 02/18 15:00 | 7 | [15] Unam Pumas U23 v Santos Laguna U23 [11] | L | 3-0 | |
| Meksyk - Liga U23 | 02/10 17:00 | 6 | [10] Santos Laguna U23 v Tigres UANL U23 [3] | D | 1-1 | |
| Meksyk - Liga U23 | 02/04 15:00 | 5 | [18] Atlas U23 v Santos Laguna U23 [8] | L | 3-2 | |
| Meksyk - Liga U23 | 01/30 17:00 | 4 | [5] Santos Laguna U23 v Puebla U23 [14] | D | 1-1 | |
| Meksyk - Liga U23 | 01/27 15:00 | 3 | Leon U23 v Santos Laguna U23 | W | 0-4 | |
| Meksyk - Liga U23 | 01/21 17:00 | 2 | [14] Santos Laguna U23 v Monterrey U23 [6] | W | 2-1 | |
| Meksyk - Liga U23 | 01/13 15:00 | 1 | Chivas Guadalajara U23 v Santos Laguna U23 | L | 3-2 | |
| Meksyk - Liga U23 | 11/18 15:00 | 3 | [2] Chivas Guadalajara U23 v Santos Laguna U23 [7] | L | 3-1 | |
| Meksyk - Liga U23 | 11/15 17:00 | 3 | [7] Santos Laguna U23 v Chivas Guadalajara U23 [2] | L | 2-4 | |
| Meksyk - Liga U23 | 11/11 15:00 | 17 | [18] Atletico San Luis U23 v Santos Laguna U23 [8] | D | 2-2 | |
| Meksyk - Liga U23 | 11/05 17:00 | 16 | [9] Santos Laguna U23 v Toluca U23 [15] | W | 2-1 | |
| Meksyk - Liga U23 | 11/01 16:00 | 15 | [9] Mazatlan FC U23 v Santos Laguna U23 [7] | L | 2-1 | |
| Meksyk - Liga U23 | 10/29 17:00 | 14 | [7] Santos Laguna U23 v Juarez FC U23 [8] | D | 0-0 | |
| Meksyk - Liga U23 | 10/21 15:00 | 13 | [7] Club America U23 v Santos Laguna U23 [9] | L | 3-2 | |
| Meksyk - Liga U23 | 10/14 15:00 | 4 | [14] Cruz Azul U23 v Santos Laguna U23 [9] | L | 4-1 | |
| Meksyk - Liga U23 | 10/08 15:00 | 12 | Santos Laguna U23 v Leon U23 | D | 0-0 | |
| Meksyk - Liga U23 | 10/04 17:00 | 11 | Santos Laguna U23 v Tijuana U23 | W | 5-0 | |
| Meksyk - Liga U23 | 09/30 15:00 | 10 | Monterrey U23 v Santos Laguna U23 | W | 1-2 | |
| Meksyk - Liga U23 | 09/24 17:00 | 9 | [11] Santos Laguna U23 v Necaxa U23 [7] | W | 5-0 | |
| Meksyk - Liga U23 | 09/18 15:30 | 8 | [2] Pachuca U23 v Santos Laguna U23 [9] | L | 2-0 |