Stadium: Enterprise Center Round: 3
Home Manager: Darian DeVries Away Manager: Bryan Mullins
| NCAAB | 2022/02/26 21:00 | Southern Illinois v Drake | L | 60-62 |
| NCAAB | 2022/01/18 01:00 | Drake v Southern Illinois | L | 60-59 |
| NCAAB | 2021/01/05 00:00 | Southern Illinois v Drake | L | 55-86 |
| NCAAB | 2021/01/03 23:00 | Southern Illinois v Drake | L | 55-73 |
| NCAAB | 2020/02/01 23:00 | Southern Illinois v Drake | W | 79-72 |
| NCAAB | 2020/01/19 21:00 | Drake v Southern Illinois | W | 49-66 |
| NCAAB | 2019/02/13 01:00 | Drake v Southern Illinois | L | 72-69 |
| NCAAB | 2019/01/09 01:00 | Southern Illinois v Drake | L | 70-82 |
| NCAAB | 2022/02/26 21:00 | Southern Illinois v Drake | L | 60-62 |
| NCAAB | 2022/02/24 01:00 | Illinois St v Southern Illinois | W | 69-90 |
| NCAAB | 2022/02/19 18:00 | Southern Illinois v Indiana State | W | 76-72 |
| NCAAB | 2022/02/16 01:00 | Bradley v Southern Illinois | W | 57-65 |
| NCAAB | 2022/02/13 01:00 | Evansville v Southern Illinois | W | 62-69 |
| NCAAB | 2022/02/10 01:00 | Southern Illinois v Northern Iowa | L | 44-53 |
| NCAAB | 2022/02/06 01:00 | Southern Illinois v Illinois St | W | 75-69 |
| NCAAB | 2022/02/03 02:00 | Missouri State v Southern Illinois | L | 69-54 |
| NCAAB | 2022/02/26 21:00 | Southern Illinois v Drake | W | 60-62 |
| NCAAB | 2022/02/24 00:00 | Drake v Valparaiso | W | 71-65 |
| NCAAB | 2022/02/22 01:00 | Indiana State v Drake | W | 58-74 |
| NCAAB | 2022/02/19 23:00 | Drake v Loyola Chicago | W | 83-76 |
| NCAAB | 2022/02/17 01:00 | Evansville v Drake | W | 51-73 |
| NCAAB | 2022/02/13 01:00 | Drake v Bradley | L | 59-68 |
| NCAAB | 2022/02/10 01:00 | Missouri State v Drake | L | 66-62 |
| NCAAB | 2022/02/05 23:00 | Northern Iowa v Drake | L | 74-69 |