Stadium: Memorial Gymnasium
Home Manager: Jerry Stackhouse Away Manager: Mark Prosser
| NCAAB | 2021/11/17 00:00 | Winthrop v Middle Tenn St | L | 65-76 |
| NCAAB | 2021/11/13 19:00 | Mercer v Winthrop | W | 85-88 |
| NCAAB | 2021/11/09 23:00 | Winthrop v Mary Baldwin | W | 110-78 |
| NCAAB | 2021/03/20 02:10 | Winthrop v Villanova | L | 63-73 |
| NCAAB | 2021/03/07 17:00 | Campbell v Winthrop | W | 53-80 |
| NCAAB | 2021/03/05 00:30 | Longwood v Winthrop | W | 61-82 |
| NCAAB | 2021/03/01 23:00 | High Point v Winthrop | W | 54-83 |
| NCAAB | 2021/02/20 00:00 | Winthrop v High Point | W | 71-63 |
| NCAAB | 2021/11/18 01:00 | VA Commonwealth v Vanderbilt | L | 48-37 |
| NCAAB | 2021/11/15 01:00 | Texas State v Vanderbilt | W | 60-79 |
| NCAAB | 2021/11/11 01:00 | Alabama State v Vanderbilt | W | 72-91 |
| NCAAB | 2021/03/11 19:30 | Vanderbilt v Florida Gators | L | 63-69 |
| NCAAB | 2021/03/11 00:00 | Texas A&M v Vanderbilt | W | 68-79 |
| NCAAB | 2021/03/07 00:00 | Vanderbilt v Mississippi | L | 46-56 |
| NCAAB | 2021/03/05 00:00 | Vanderbilt v Cincinnati | W | 78-64 |
| NCAAB | 2021/03/03 01:30 | Vanderbilt v LSU | L | 68-83 |