Stadium: Banterra Center
Home Manager: Bryan Mullins Away Manager: Darian DeVries
| NCAAB | 2021/01/05 00:00 | Southern Illinois v Drake | W | 55-86 |
| NCAAB | 2021/01/03 23:00 | Southern Illinois v Drake | W | 55-73 |
| NCAAB | 2020/02/01 23:00 | Southern Illinois v Drake | L | 79-72 |
| NCAAB | 2020/01/19 21:00 | Drake v Southern Illinois | L | 49-66 |
| NCAAB | 2019/02/13 01:00 | Drake v Southern Illinois | W | 72-69 |
| NCAAB | 2019/01/09 01:00 | Southern Illinois v Drake | W | 70-82 |
| NCAAB | 2018/01/31 01:00 | Southern Illinois v Drake | L | 78-67 |
| NCAAB | 2017/12/31 21:00 | Drake v Southern Illinois | W | 70-67 |
| NCAAB | 2022/01/13 01:00 | Illinois St v Drake | W | 75-86 |
| NCAAB | 2022/01/08 22:00 | Drake v Evansville | W | 60-59 |
| NCAAB | 2022/01/03 01:00 | Drake v Missouri State | L | 56-61 |
| NCAAB | 2021/12/29 01:00 | Drake v Mount Marty | W | 82-53 |
| NCAAB | 2021/12/22 23:00 | Chicago St v Drake | W | 50-87 |
| NCAAB | 2021/12/19 20:00 | Tennessee Martin v Drake | W | 54-80 |
| NCAAB | 2021/12/17 01:00 | Jackson State v Drake | W | 65-70 |
| NCAAB | 2021/12/11 19:00 | Drake v Clemson | L | 80-90 |
| NCAAB | 2022/01/16 01:00 | Northern Iowa v Southern Illinois | L | 69-68 |
| NCAAB | 2022/01/13 01:00 | Southern Illinois v Missouri State | L | 76-81 |
| NCAAB | 2022/01/09 00:00 | Southern Illinois v Valparaiso | W | 63-60 |
| NCAAB | 2021/12/29 01:00 | Grambling State v Southern Illinois | W | 64-75 |
| NCAAB | 2021/12/22 22:00 | Southern Illinois v San Francisco | L | 52-64 |
| NCAAB | 2021/12/18 21:00 | Southern Illinois v Maryville | W | 75-55 |
| NCAAB | 2021/12/16 01:00 | SE Missouri State v Southern Illinois | W | 55-80 |
| NCAAB | 2021/12/11 19:00 | Southern Illinois v Tulsa | L | 65-69 |