[2] BUF Sabres 1-2 NJ Devils [12] 2021-10-23 23:00
Stadium: Prudential Center
Home Manager: Lindy Ruff Away Manager: Don Granato
Head to Head
| NHL | 2021/04/08 23:00 | NJ Devils v BUF Sabres | L | 6-3 |
| NHL | 2021/04/06 23:00 | BUF Sabres v NJ Devils | W | 5-3 |
| NHL | 2021/03/16 23:00 | BUF Sabres v NJ Devils | L | 2-3 |
| NHL | 2021/02/26 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/02/24 00:00 | BUF Sabres v NJ Devils | W | 4-1 |
| NHL | 2021/02/20 17:30 | BUF Sabres v NJ Devils | W | 3-2 |
| NHL | 2021/01/31 18:00 | NJ Devils v BUF Sabres | L | 5-3 |
| NHL | 2021/01/30 18:00 | NJ Devils v BUF Sabres | W | 3-4 |
Home History
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/10/19 23:00 | VAN Canucks v BUF Sabres | W | 2-5 |
| NHL | 2021/10/16 17:00 | ARZ Coyotes v BUF Sabres | W | 1-2 |
| NHL | 2021/10/14 23:00 | MON Canadiens v BUF Sabres | W | 1-5 |
| NHL - Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL - Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL - Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |
| NHL - Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
Away History
| NHL | 2021/10/21 23:00 | WAS Capitals v NJ Devils | L | 4-1 |
| NHL | 2021/10/19 23:00 | SEA Kraken v NJ Devils | W | 2-4 |
| NHL | 2021/10/15 23:00 | CHI Blackhawks v NJ Devils | W | 3-4 |
| NHL - Pre-Season | 2021/10/06 23:00 | NJ Devils v NY Rangers | L | 2-6 |
| NHL - Pre-Season | 2021/10/04 23:00 | WAS Capitals v NJ Devils | W | 1-4 |
| NHL - Pre-Season | 2021/10/02 18:00 | NJ Devils v NY Islanders | W | 2-1 |
| NHL - Pre-Season | 2021/10/01 23:00 | NY Rangers v NJ Devils | W | 1-7 |
| NHL - Pre-Season | 2021/09/29 23:00 | NJ Devils v WAS Capitals | W | 5-4 |
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